Zentrum für Zahn-, Mund- und Kieferheilkunde der Universitätsmedizin Greifswald

OA Dr. Mohammad Alkilzy

Kontakt:

OA Dr. Mohammad Alkilzy
Präventive Zahnmedizin und Kinderzahnheilkunde
Behandlung: Walther-Rathenau-Straße 42
Büro: Fleischmannstraße 42-44
17475 Greifswald

Tel:0 38 34 - 86 71 36

Ausbildung

1992-1997 Studium Zahnmedizin in Aleppo Universität/Syrien
1997 D.D.S (Doctor Dental Surgeon)
1998 - 2000 Postgraduale Ausbildung in Kinderzahnheilkunde in Damaskus Universität/Syrien
2000 Titel "Spezialist in Kinderzahnheilkunde"
2000 - 2003 Wissenschaftlicher Mitarbeiter in der Abteilung für Kinderzahnheilkunde/Aleppo Universität
seit 2003 Wissenschaftlicher Mitarbeiter in der Abteilung für Präventive Zahnmedizin und  Kinderzahnheilkunde/Universität Greifswald- Deutschland
Juli 2009 Dr. med. dent. (PhD), Promotion zur Thema „Therapeutic Sealing of Proximal Tooth Surfaces: Two-Year Clinical and Radiographic Evaluation” Universität Greifswald


Forschungsschwerpunkte

- Verteilung und Ätiologie von Dysgnathien bei Kinderzahnheilkundepatienten.
- Sealing of proximal surfaces with polyurethane tape" addieren
- Clinical applicability and safety of resin infiltration of proximal caries


Publications:


Alkilzy M. A severe case of primary herpetic gingivostomatitis. Journal of Syrian Dental Association, (4), 2005.

Alkilzy M, Shaaban A, Altinawi M, Splieth Ch. Epidemiology and aetiology of malocclusion among Syrian paediatric patients. European Journal of Paediatric Dentistry, 2007 Sep;8:131-5.

Alkilzy M, Berndt Ch, Meller Ch, Schidlowski M, Splieth Ch. Sealing of proximal surfaces with polyurethane tape: a two-year clinical and radiographic feasibility study. J Adhesive Dent, 2009;11:91-94.

Splieth CH, Ekstrand KR, Alkilzy M, Clarkson J, Meyer-Luckel H, Martignon S, Paris S, Pitts N, Ricketts DJN and van Loveren C. Sealants in dentistry: dental education, knowledge and guidelines. – Caries Research – accepted for publication, 2008

Alkilzy M, Berndt C, Splieth Ch. Therapeutic Sealing of Proximal Tooth Surfaces: Three-Year Clinical and Radiographic Follow-Up. Caries Res 2008;42:196 (Abstr No. 32).

Alkilzy M, Heyduck C, Meller C, Schidlowski M, Splieth Ch. Therapeutic sealing of proximal tooth surfaces: Two-year follow-up. Caries Res 2007;41:273 (Abstr No. 16).

Alkilzy M, Heyduck C, Meller C, Schidlowski M, Splieth Ch. Therapeutic Sealing of Proximal Tooth Surfaces: 6-month Follow-up. Caries Res 2006;40:328 (Abstr No. 73).

Ch. Splieth, M. Schidlowski, Ch. Heyduck, M. Alkilzy. Respons und Nonrespons bei einem Kariespräventionsprogramm. Oralprophylaxe & Kinderzahnheilkunde Sep. 2007;29:113-116.

Splieth C, Heyduck C, Alkilzy M, Meller C: Dental-Pisa: Zusammenhang von oraler Gesundheit und Bildungsstatus – eine 10 Jahres-follow-up-Studie. Autoreferate-Band, Wissenschaftliches Programm der 13. Jahrestagung der Deutschen Gesellschaft für Kinderzahnheilkunde 2006, Quintessenz Verlag, Berlin 2006.

Splieth C, Alkilzy M, Schmitt J, Berndt C, Welk A. Effect of xylitol and sorbitol on plaque acidogenesis. Quintessence International 2009;40:279–285.

Alkilzy M, Berndt Ch, Splieth Ch. Sealing proximal surfaces with polyurethane tape: three-year evaluation. Clin Oral Invest, OnlineFirst 10. Aug. 2010.

Abstracts:


Sealing of proximal surfaces with polyurethane tape: a two-year clinical and radiographic feasibility study.
Alkilzy M, Berndt C, Meller C, Schidlowski M, Splieth C.
J Adhes Dent. 2009 Apr;11(2):91-4.

PURPOSE: Proximal carious lesions comprise a constant clinical problem. The aim of this investigation was to test the safety and clinical effect of a new treatment for proximal caries. MATERIALS AND METHODS: In 50 patients with two proximal initial lesions (D1-3 without cavitation, bitewing radiograph), orthodontic rubber rings were applied to gain access to the interproximal space. One of the lesions was sealed with a thin polyurethane-dimethacrylate foil using a bonding agent; the other lesion received oral home care with dental floss and fluoridated toothpaste, and was left as control. RESULTS: In clinical follow-ups after 6 and 12 months and radiographic evaluation after two years, clinical retention of proximal tape and the underlying sealant, marginal adaptation, discoloration, tooth vitality, proximal plaque, and gingivitis were checked. In addition, carious lesions were assessed clinically and radiographically. The sealants showed good retention, marginal adaptation, and color. After two years, vitality of all teeth was still positive and no relevant differences in plaque accumulation or gingival status were found between sealed and control teeth. Nine sealed lesions showed caries regression and 2 progression. In contrast, only 4 control lesions regressed and also 2 showed progression. The loss of tape had no significant influence on the lesion progression, indicating the effect of the underlying bond. All other sealants and control lesions were stable, indicating an arrest of the lesion. CONCLUSION: Sealing initial proximal lesions showed no clinical problems and mostly arrest of initial carious lesions on bitewing radiographs.


Epidemiology and aetiology of malocclusion among Syrian paediatric patients.
Alkilzy M, Shaaban A, Altinawi M, Splieth ChH.
Eur J Paediatr Dent. 2007 Sep;8(3):131-5.

AIM: The knowledge of the distribution and causes of malocclusion in early childhood can prevent such malocclusions and their consequences and possibly to reduce complex orthodontic treatment. METHODS: All children (n = 234; 116 male, 118 female, age 2-16) who presented with occlusal or functional problems at the Department of Paediatric Dentistry at Damascus University (1995-1999) were classified according to the type and causes of malocclusion and the subsequent orthodontic treatment. RESULTS: 57.3% of the malocclusions affected the anterior-posterior plane, 12.4% the vertical, and 35.9% the transverse. Most of the malocclusions had causes which could be modified by preventive or interceptive efforts: thumb sucking (5.12%), infantile swallowing (3.84%), mouth breathing (0.85%), tongue thrusting (1.7%), delayed exfoliation of a primary tooth (3.41%), premature loss of a primary tooth (9.82%), delayed eruption of a permanent tooth (2.13%), or an impacted tooth (6.41%). The subsequent early orthodontic treatment consisted of space maintainers (26%), removable (40.9%), functional (11.9%), or fixed appliances (21.2%). CONCLUSION: These data stress the importance of early orthodontic diagnosis in paediatric practice. Malocclusion in this Syrian sample could be treated to a great extent with preventive or interceptive orthodontics, which required only simple appliances and techniques.


Correlation between caries and nutrition among 5th grad German school children
M Alkilzy, J Wittmeier, S Alsoliman, S Plachta-Danielzik , MJ Müller , C. H. Splieth

Nutrition plays an important role in oral health. Thus, this exploratory study investigated current diet patterns, its individual variation and the association with dental caries in children. The sample comprised 852 schoolchildren in 5th grade (9-13 years) in Greifswald and Pomerania. In conjunct with the compulsory, dental community examination, additional data about dietary content and frequency (food frequency index, 4 weeks) were collected by two questionnaires for the children and their parents.
The distribution of the DMFT values was highly polarized with most of the children exhibiting no carious defects, fillings or missing teeth in the permanent dentition (Ø 0.6 ±1.2 DMFT). The associations between the DMFT and certain food items were divided into statistically non-significant correlations and significant correlations with the DMFT (Spearman-Rho correlation coefficient). The frequency of drinking lemonade or ice tea and eating salty snacks (chips, nuts) showed clear correlations with the DMFT (rs=0.16 and 0.14, p<0.01). White bread (rs=0.07, p=0.05) and sweets/cakes (rs=0.07, p=0.06) showed only a weak correlation. Items such jam, honey, cereals, fruit/vegetables, tea with/without sugar, fruit juice and (chocolate) milk showed no association with caries at all.
Taking water to school for drinking was associated with less caries, ice tea and lemonade with higher caries levels (rs =-0.13, 0.09 and 0.08, respectively, p <0.01).
Children who rated a good taste of food as most important had significantly higher DMFT scores than children who did not (0.7 ±1.3 vs 0.4 ±1.0, p=0.01).
In conclusion, convenience food and drinks seem to influence caries prevalence in children.


Sealing Proximal Surfaces with Polyurethane Tape: Three-Year Evaluation
M. Alkilzy, Ch. Berndt, Ch. Splieth

The purpose of this investigation was to test the safety and clinical effect of a new material for the treatment of proximal caries. In 50 patients with two proximal initial lesions, one of the lesions was randomly chosen and sealed with a thin polyurethane-dimetacrylate foil using bonding; the other lesion received oral home-care and was left as the control. In clinical follow-ups after 6 and 12 months and X-ray evaluation after two and three years, the sealants showed good retention, marginal adaptation and color. No relevant significant differences in plaque accumulation or gingival status were found between sealed and control teeth. On the radiographs, almost all sealed and control lesions appeared stable, indicating an arrest of the lesion. In conclusion, sealing initial proximal lesions showed no clinical problems and mostly arrest of caries on bitewing radiographs.


Approximalversiegelung mit Polyurethanfolie: Klinische und radiographische 2 - Jahresergebnisse
M. Alkilzy , Ch. Berndt, Ch. Meller, M. Schidlowski, Ch. Splieth

Das Ziel dieser Studie war, die Sicherheit und klinische Wirkung einer neuen Therapie für approximale Karies zu prüfen. Bei 50 Patienten (27 männlich, 23 weiblich, Alter 8 – 30; Ø = 21.3 ± 5.6 J.) mit zwei approximalen kariösen Initialläsionen (D1-3 ohne cavitation, Bissflügelröntgenaufnahme) wurden kieferorthopädische Separiergummis eingesetzt, um Zugang zum Approximalraum zu gewinnen. Eine der Läsionen wurde mit Bonding (Heliobond®, Vivadent, Schaan/Liechtenstein) und einer dünnen Folie aus Polyurethandimethacrylat versiegelt. Für die andere Läsion erfolgte eine Mundhygieneinstruktion des Patienten mit Zahnseide und fluoridierte Zahnpasta, was als Kontrolle diente.
In klinischen (1/2, 1, 2 Jahre) und röntgenologischen Kontrollen (2 Jahre) wurden die klinische Retention der approximalen Versiegelung, marginale Adaptation, Farbe, Vitalität der Zähne, approximale Plaque und Gingiva überprüft. Zusätzlich wurde Karies klinisch und radiologisch bewertet.
Die Versiegelungen zeigten sehr gute Retention, gute marginale Adaptation und Farbe nach zwei Jahren (n = 36). Die Vitalität aller Zähne war positiv und keine relevanten Unterschiede wurden bezüglich Plaque bzw. Gingivitis zwischen versiegelten und Kontrollzähnen gefunden. Zwei versiegelte Approximalfläche mussten wegen des Kariesprogression (D3 mit Kavitation) gefüllt werden. 9 versiegelte Läsionen zeigten Kariesregression. Bei den Kontrollläsionen traten 4 Regression und ebenfalls zwei Progression auf. Der Totalverlust der Folie hatte keinen Einfluss auf den Kariesprogression, was an der Wirkung des Bondings liegen könnte. Alle anderen versiegelten und Kontrollläsionen waren stabil, was eine Arretierung der Läsionen vermuten lässt. Schlussfolgernd ergibt sich, dass die Versiegelung der initialen approximalen Lesionen keine klinischen Probleme und mehrheitlich Arretierung von kariösen Initialläsionen auf Bissflügelröntgenaufnahmen zeigte.


Verteilung und Ätiologie von Dysgnathien bei Kinderzahnheilkundepatienten
M. Alkizy, A. Sa'ban, M. Altinawi, Ch. Splieth

Kenntnisse über die Verteilung und Ätiologie von Dysgnathien in der Kindheit können bei der Allokation von präventiven und therapeutischen Ressourcen helfen. Alle Kinder (n=234; 116 m, 118 w), die zwischen 1995 und 1999 die Abteilung für Kinderzahnheilkunde der Universität Damaskus/Syrien mit einer Dysgnathie oder funktionellen Problemen aufsuchten, wurden 5 Altersgruppen zugeordnet [2-5 J. (3,8%), 6-8 J. (18,8%), 9-11 J. (36,8%), 12-14 J. (37,2%), 15-16 J. (3,4%)]. Danach erfolgte eine Klassifizierung der Dysgnathie/funktionellen Störung und deren Ätiologie sowie der nachfolgenden präventiven bzw. interzeptiven kieferorthopädischen Therapie.
57,3% der Dysgnathien betrafen die sagittale Ebene, 12,4% die Vertikale und 35,9% die Transversale, wobei einzelne Dysgnathien mehrere Ebenen betrafen. Die meisten Dysgnathien hatten Ursachen, die präventiv oder interzeptiv beeinflussbar wären: Trauma 2,1%, Lutschhabit 5,1%, infantiles Schluckmuster 3,8%, Mundatmung 0,8%, Zungenpressen 1,6%, Zahnüberzahl 3,8%, Zahnunterzahl 4,2%, verspäteter Milchzahndurchbruch 3,2%, frühzeitiger Milchzahnverlust 9,8%, verspäteter Durchbruch eines permanenten Zahnes 2,1%, impaktierte Zähne 6,3%. Die nachfolgende Behandlung bestand zu 26% aus Lückenhaltern, 40,9% einfachen herausnehmbaren Apparaturen, 11,9% funktionskieferorthopädischen Maßnahmen und 21,2% festen Apparaturen.
Diese Daten verdeutlichen die Bedeutung der kieferorthopädischen Diagnostik in der kinderzahnheilkundlichen Praxis. Die häufigste Ursache für Dysgnathien/funktionelle Störungen war der frühzeitige Milchzahnverlust, der zumeist problemlos durch Lückenhalter kompensiert werden kann. Insgesamt wären 43,6% der Dysgnathien/funktionellen Störungen durch eine frühzeitige präventive oder interzeptive Behandlung mit einfachen Maßnahmen oder Geräten im Rahmen der kinderzahnheilkundlichen Betreuung therapierbar, wodurch z. T. umfangreiche spätere kieferorthopädische Behandlungen mit hohen Kosten vermieden werden können.


Therapeutic Sealing of Proximal Tooth Surfaces: Two-year follow-up
The purpose of this investigation was to test the effect of a new treatment for proximal caries. In 32 patients with two proximal caries (D1-3 without cavitation, bitewing X-ray) orthodontic rubber rings were applied to gain access to the interproximal space. One of the lesions was sealed with a thin polyurethane-dimetacrylate foil using a bonding agent (Heliobond®, Vivadent, Schaan/Liechtenstein); the other lesion received oral home-care with dental floss and fluoridated toothpaste and was left as control. In clinical and X-ray follow-up after two years of application, clinical retention of proximal tape and the underlying sealant, marginal adaptation, discoloration, tooth vitality, plaque and gingivitis were checked; in addition caries was assessed clinically and radiographically.
The sealants showed excellent retention, good marginal adaptation and colour. After two years, vitality of all teeth was still positive and no differences in plaque accumulation or gingival status were found between sealed and control teeth. In two patients, an evaluation was not possible due to orthodontic bands and changing of dentists. One sealed surface had to be filled due to caries progression (D3 with cavitation) after a partial loss of the proximal tape. 11 sealed lesions showed regression, while two progressed. In contrast, only 6 control lesions regressed and also two showed progression. The loss of tape had no significant influence on the lesion progression indicating the effect of underlying bond. All other sealants and control lesions were stable indicating an arrest of the lesion. In conclusion, sealing initial proximal lesions showed no clinical problems and a considerable amount of regression of the lesion on bitewing X-ray, while recommendations to floss and fluorides resulted in less regression, but also very little progression at the two-year follow-up.

Poster:


Clinical applicability and safety of resin infiltration of proximal caries.
M Alkilzy and C. H. Splieth.


Correlation between caries and nutrition among 5th grad German school children

Therapeutic Sealing of Proximal Tooth Surfaces: Three-year clinical and radiographic follow-up

Verteilung und Ätiologie von Dysgnathien bei Kinderzahnheilkundepatienten.

Therapeutic Sealing of Proximal Tooth Surfaces: Two-year follow-up"
presented at the 54rd Congress of the European Organization for Caries Research (ORCA), Helsingor, Denmark July 4-7, 2007


Epidemiology and etiology of malocclusion among pedodontic patients
Dr. M. Alkilzy/Dept. of Preventive and Pediatric Dentistry/University of Greifswald/Germany

Dr. A. Sha'ban/Dept. of Pediatric Dentistry/University of Damascus/Syria

Prof. Dr. M. Altinawi/ Dept. of Pediatric Dentistry/University of Damascus/Syria

Prof. Dr. Ch. H. Splieth/Dept. of Preventive and Pediatric Dentistry/University of Greifswald/Germany

Objectives: The knowledge of prevalence and causes of malocclusion in early childhood can prevent such malocclusion and their consequences and allow to reduce complex orthodontic treatment.

Methods: All children (n=234; 116 male, 118 female) who presented with occlusal or functional problems to the Pedodontics Department at Damascus University (1995-1999) were divided into 5 age groups [age distribution: 2-5 years (3.5%), 6-8 (18.8%), 9-11 (36.8%), 12-14 (37.1%), 15-16 (3.4%)]. They were classified according to the kind and causes of malocclusion and the subsequent orthodontic treatment.

Results: 57.3% of the malocclusion affected the anterior-posterior plane, 12.4% the vertical plane and 35.9% the lateral plane. Most of the malocclusions had causes which could be modified by preventive or interceptive efforts: trauma (2.1%), thumb sucking (5.1%), infantile swallowing (3.8%), mouth breathing (0.8%), tongue thrusting (1.6%), hyperdontia (3.8%), hypodontia (4.2%), delayed eruption of a primary tooth (3.2%), premature loss of a primary tooth (9.8%), delayed eruption of a permanent tooth (2.1%), an impacted tooth (6.3%). The subsequent pedodontic treatment consisted of space maintainers (26%), simple removable appliances (40.9%), functional appliances (11.9%), and fixed appliances (21.2%).

Conclusion: These data stress the importance of orthodontic diagnostics in pedodontic practice, especially from age 9-14. The most important single reason for malocclusion was the premature loss of primary teeth, which can easily be compensated by space maintainers. In total, 43.6% of malocclusion of this Syrian sample could be treated with preventive or interceptive orthodontics which required only simple appliances and techniques, but avoided complex and expensive orthodontic treatment.

Keywords:  malocclusion, early orthodontic treatment, children.